Black Oranda Eyeless Runt

In my "pet store trough" where I put fry culled from a stock that have pet potential this little guy stood out. It was sunny, all the other fish in the tub were hiding from my silhouette against the bright sky and this little guy kept on his merry way. 

Turns out both eyes are long gone, genetics or removed by its siblings, will never be known. It is by far the smallest and blackest of this black Oranda spawn, now if I could just get the tail and color this good on the rest of the stock, things would be too easy. 

It has already been under ice once this year, so far it's a hardy little guy. 

Pink transparent and Blue ramshorn snail

Effects of praziquantel and sanguinarine on expression of immune genes and susceptibility to Aeromonas hydrophila in goldfish (Carassius auratus) infected with Dactylogyrus intermedius.

Effects of praziquantel and sanguinarine on expression of immune genes and susceptibility to Aeromonas hydrophila in goldfish (Carassius auratus) infected with Dactylogyrus intermedius. 
Fish Shellfish Immunol. 2013 Oct;35(4):1301-8. doi: 10.1016/j.fsi.2013.08.001. Epub 2013 Aug 15.

Abstract

Praziquantel and sanguinarine have been demonstrated positive therapeutic effects on monogenean Dactylogyrus intermedius; however, few studies have considered the post impacts of these antiparasitic chemicals on host after repelling the parasites. The changes of expression of selected immune genes (CCL-1, CXCL-8, IL-1β-1, IL-1β-2, TNFα-1, TNFα-2 and TGF-β) in gill, kidney and spleen and bacterial loads of Aeromonas hydrophila in gill, kidney, spleen and liver following bath administration of these antiparasitic chemicals were evaluated. The results showed that praziquantel and sanguinarine up-regulated to varying degrees of CXCL-8, IL-1β-1, IL-1β-2, TNFα-1 and TNFα-2 in gill, kidney and spleen. They both decreased the CCL-1 expression in gill while increased it in kidney and spleen. However, in all the tested tissues, the expression of TGF-β decreased in praziquantel treated goldfish whereas that increased in sanguinarine treated goldfish. The A. hydrophila challenge test showed that the praziquantel treatment enhanced the susceptibility to A. hydrophila while sanguinarine treatment decreased the susceptibility, as compared with the non-treated group. Overall, the results indicate that bath administration of praziquantel and sanguinarine modulates the immune related genes in goldfish and these may, to some extent, affect their ability to resist bacterial pathogens. Copyright © 2013 Elsevier Ltd. All rights reserved.

http://www.ncbi.nlm.nih.gov/pubmed/23954698